Abstract

The synthesis procedure and the spectral luminescent properties of nanoparticles containing the ytterbium complex of protoporphyrin IX dimethyl ester in a Lexan-based polymer matrix, promising for application in neoplasm diagnostics, are described. Nanoparticles have an increased luminescence lifetime in the 700–1100 nm near infrared region and almost no porphyrin free base fluorescence in the red spectral region, which shows promise in using the nanoparticles for diagnostic purposes. For theranostic purposes, the synthesis of multifunctional nanoparticles with a core of iron oxides and a Lexan-polymer shell containing the ytterbium complex of hematoporphyrin IX tetramethyl ester was carried out. We assume iron oxide nanoparticles are responsible for the local hyperthermia procedure.

中文翻译：

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基于Lexan聚合物基质，卟啉phy配合物和氧化铁的复合纳米粒子用于NIR发光诊断和肿瘤治疗

摘要

描述了在基于Lexan的聚合物基质中含有原卟啉IX二甲酯的complex配合物的纳米颗粒的合成方法和光谱发光特性，有望应用于肿瘤诊断。纳米粒子在700-1100 nm的近红外区域具有更长的发光寿命，而在红色光谱区域几乎没有卟啉游离碱荧光，这显示出将纳米粒子用于诊断目的的希望。出于治疗的目的，合成了具有铁氧化物核和含有血卟啉IX四甲酯y配合物的Lexan-聚合物壳的多功能纳米颗粒。我们假设氧化铁纳米颗粒负责局部热疗程序。