Abstract

This paper studies some parameters of animals’ immune status in case of combination and traditional therapy. The positive dynamics of circulating immune complexes (CICs) in the blood flow and restoration of the composition of white blood cells after combination therapy of sheep with spontaneous invasion with gastrointestinal strongylata were revealed. Preliminary subcutaneous double injections of ribotane at a dose of 0.05 mL/kg and fenbendazole given once orally at a therapeutic dose of 5 mg/kg cause a significant remission of the CICs in the blood flow of animals (74.3 ± 3.49 un.opt.dens. E₄₅₀; p < 0.05) and prevent the development of functional disorders of blood formation, restoring the composition of white blood cells (lymphocytes and eosinophils) to the initial level in the early stages after the administration of the drugs. The studies have shown that the remission of the CICs and restoration of blood formation are a reflection of the effectiveness of treatment and completion of the pathological process. The possible mechanisms of immune complexes' clearance in the circulation and causes for the restoration of the composition of white blood cells after the combined treatment are discussed.

中文翻译：

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胃肠道强韧化综合治疗中循环免疫复合物的水平和血液学特征

摘要

本文结合传统疗法研究了动物免疫状态的一些参数。揭示了羊自发侵袭性胃肠道强直疗法联合治疗后，循环免疫复合物（CIC）在血流中的积极动态和白细胞组成的恢复。初步皮下两次注射剂量为0.05 mL / kg的核黄素和以5 mg / kg的治疗剂量口服一次芬苯达唑引起动物血流中CIC的显着缓解（74.3±3.49 un.opt.dens E ₄₅₀ ;第<0.05）并防止血液形成功能障碍的发展，在给药后的早期将白细胞（淋巴细胞和嗜酸性粒细胞）的组成恢复到初始水平。研究表明，CIC的缓解和血液形成的恢复反映了治疗的有效性和病理过程的完成。讨论了免疫复合物在循环中清除的可能机制，以及联合治疗后白细胞组成恢复的原因。