Abstract

The reaction of chloromethyl propargyl ether with 4-(bromomethyl)benzaldehyde in the presence of zinc metal and a chiral ligand, N-ethyl-N-{[(2S)-pyrrolidin-2-yl]methyl}ethanamine, gave 1-[(4-(bromomethyl)phenyl]-2-(prop-2-yn-1-yloxy)ethanol with a moderate yield and high selectivity.

中文翻译：

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1-[（4-（溴甲基）苯基] -2-（prop-2-yn-1-yloxy）乙醇的绝对构型的确定

摘要

氯甲基炔丙基醚与4-（溴甲基）苯甲醛在锌金属和手性配体N-乙基-N -{[（2 S）-吡咯烷-2-基]甲基}乙胺的存在下反应，得到1- [（4-（溴甲基）苯基] -2-（丙-2-炔-1-基氧基）乙醇具有中等收率和高选择性。