Abstract — Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutamic acid residue in the Glu-His-OMe and Glu-His-Trp-OMe compounds by its cyclic form, as well as the introduction of the D Tyr and D Ala residues into the sequence Asp-Tyr-Ala-Pro, was shown to double their ability to bind interleukin-8.

中文翻译：

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寡肽的修饰提高其与人血浆中白细胞介素 8 相互作用的有效性

摘要 — 进行分子建模，确定了几个肽序列，以寻找能够降低人血浆中白细胞介素 8 浓度的化合物。将 Glu-His-OMe 和 Glu-His-Trp-OMe 化合物中的谷氨酸残基替换为其环状形式，以及将 D Tyr 和 D Ala 残基引入序列 Asp-Tyr-Ala- Pro，被证明可以使它们结合白细胞介素 8 的能力加倍。