The Brain cytoplasmic 200 RNA (BC200 RNA) is neuron-specific lncRNA with putative roles in normal aging and in the pathogenesis of Alzheimer’s disease. Its role in the neuron plasticity has also been documented. In the current study, we genotyped a single nucleotide polymorphism (SNP) within this lncRNA (rs4404327) in a population of Iranian patients with diverse neuropsychiatric conditions including substance addiction (n = 315), attention deficit hyperactive disorder (ADHD) (n = 53), bipolar 1 (BP1) (n = 131), bipolar 2 (BP2) (n = 68), major depressive disorder (MDD) (n = 56) and schizophrenia (SCZ) (n = 177) as well as age−/ sex-matched healthy controls. This SNP was associated with ADHD in co-dominant model (C/T vs. C/C) (OR (95% CI) = 3.7 (1.96–10), P value = 0.000193), dominant model (C/T + T/T vs. C/C) (OR (95% CI) = 4.43(2.02–9.72), P value = 1.37E-04) and multiplicative model (C vs. T) (OR (95% CI) = 3.20(1.64–6.25), P value = 4.316269E-04). Moreover, this SNP was associated with risk of BP1 in dominant model (OR (95% CI) = 1.67(1.08–2.62), P value = 0.02) and multiplicative model (OR (95% CI) = 1.51 (1.04–2.21), P value = 0.028). After correction for multiple comparisons (6 cohorts × 4 models), associations remained significant in ADHD but not in BP1. No other significant association was detected. The current project showed association between a certain SNP within BC200 RNA and ADHD. Further studies are required to assess these associations in larger cohorts of patients and find the underlying mechanism for this observation.

脑细胞质 200 RNA ( BC200 RNA ) 是神经元特异性 lncRNA，在正常衰老和阿尔茨海默病的发病机制中具有推定的作用。它在神经元可塑性中的作用也被记录在案。在目前的研究中，我们在一群患有多种神经精神疾病（包括物质成瘾（ n  = 315）、注意力缺陷多动障碍（ADHD）（n  = 53 ）的伊朗患者中对该 lncRNA（rs4404327）中的单核苷酸多态性（SNP）进行了基因分型。)、双相 1 (BP1) ( n  = 131)、双相 2 (BP2) ( n  = 68)、重度抑郁症 (MDD) ( n  = 56) 和精神分裂症 (SCZ) ( n = 177）以及年龄-/性别匹配的健康对照。该 SNP 与共显性模型（C/T 与 C/C）中的 ADHD 相关（OR (95% CI) = 3.7 (1.96-10)，P值 = 0.000193），显性模型（C/T + T /T vs. C/C) (OR (95% CI) = 4.43(2.02–9.72), P值 = 1.37E-04) 和乘法模型 (C vs. T) (OR (95% CI) = 3.20( 1.64–6.25），P值 = 4.316269E-04）。此外，该 SNP 与优势模型中 BP1 的风险相关（OR（95% CI）= 1.67（1.08-2.62），P值 = 0.02) 和乘法模型 (OR (95% CI) = 1.51 (1.04–2.21), P 值 = 0.028)。在校正多重比较（6 个队列 × 4 个模型）后，关联在 ADHD 中仍然显着，但在 BP1 中不显着。未检测到其他显着关联。目前的项目显示了BC200 RNA中的某个 SNP与 ADHD 之间的关联。需要进一步的研究来评估更大的患者队列中的这些关联，并找到这种观察的潜在机制。