A three-zone simulated moving bed (SMB) chromatography using ModiCon strategy is proposed to enhance the separating performance. In this approach, three fold-concentrated feed and only desorbent are introduced during one-third and two-thirds of the switching time, respectively. The results showed that if the concentrated feed is introduced during the first and the last subsection of switching time, purity of extract and raffinate are improved, respectively, while recovery and other performance indices (i.e., solvent consumption and ratio of desorbent/feed) are slightly decreased. On the other hand, introduction of concentrated feed during the middle subsection of switching time results in an increase of both raffinate and extract purity, as well as the recovery yield. Other performance indices were comparable to those of three-zone SMB without ModiCon.

中文翻译：

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使用 ModiCon 策略增强三区模拟移动床色谱的分离性能

提出了使用 ModiCon 策略的三区模拟移动床 (SMB) 色谱以提高分离性能。在这种方法中，分别在三分之一和三分之二的转换时间期间引入三倍浓缩的进料和仅解吸剂。结果表明，在切换时间的第一段和最后一段引入浓缩进料，分别提高了萃取液和萃余液的纯度，而回收率和其他性能指标（即溶剂消耗量和解吸剂/进料比）均有所提高。略有下降。另一方面，在转换时间的中间部分引入浓缩进料导致提余液和提取物纯度以及回收率的增加。