Several recent investigations show that HOX transcript antisense intergenic RNA (HOTAIR) play an important role in the pathogenesis of different cancers. HOTAIR polymorphisms has been widely studied in the context of association between with the risk of cancer pathogenesis. However, there is no certain conclusion about the role of HOTAIR polymorphisms in different cancer initiation and progression. Our team has selected eligible studies up to 1 May 2019, from several electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar databases. We have included total number of 102 case‒control investigations extracted from 41 eligible articles for the current meta-analysis. We calculated pooled odds ratio (ORs) with their corresponding 95% confidence intervals (CIs) using either fixed-effect or random-effect models for quantitative evaluation of the strength for the association between HOTAIR gene polymorphisms and the risk of cancer. Our current meta-analysis investigation showed that HOTAIR rs4759314 polymorphism particularly increased the overall risk of cancer in different models including homozygous, recessive and allele genetic. HOTAIR rs920778 significantly raised the cancer risk only in recessive genetic model. HOTAIR rs12826786 polymorphism was associated with cancer development in heterozygous, homozygous, dominant, recessive and allele genetic models. Also, an increase in cancer risk was observed with rs874945 polymorphism of HOTAIR gene in heterozygous, dominant and allele genetic models. The rs12427129 polymorphism showed correlation with cancer susceptibility only in recessive model. Subgroup analysis based on cancer type suggested that rs4759314 polymorphism significantly increased the risk of gastric and cervical cancers, and the rs920778 polymorphism increased the risk of gastrointestinal, cervical and gastric cancers. In summary, this study found that HOTAIR polymorphisms are significantly associated with cancer development.

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HOTAIR 基因与癌症风险之间的遗传关联：更新的荟萃分析

最近的几项研究表明，HOX 转录反义基因间 RNA (HOTAIR) 在不同癌症的发病机制中起着重要作用。HOTAIR 多态性已在与癌症发病机制风险之间的关联背景下得到广泛研究。然而，关于HOTAIR多态性在不同癌症发生和进展中的作用尚无定论。我们的团队已从多个电子数据库（包括 Web of Science、PubMed、Scopus 和 Google Scholar 数据库）中选择了截至 2019 年 5 月 1 日的合格研究。我们纳入了从 41 篇符合条件的文章中提取的 102 项病例对照研究，用于当前的荟萃分析。我们使用固定效应或随机效应模型计算合并优势比 (OR) 及其相应的 95% 置信区间 (CI)，以定量评估 HOTAIR 基因多态性与癌症风险之间的关联强度。我们目前的荟萃分析调查表明，HOTAIR rs4759314 多态性特别增加了不同模型中癌症的总体风险，包括纯合、隐性和等位基因遗传。HOTAIR rs920778 仅在隐性遗传模型中显着增加癌症风险。HOTAIR rs12826786 多态性与杂合子、纯合子、显性、隐性和等位基因遗传模型中的癌症发展相关。此外，在杂合、显性和等位基因遗传模型中，HOTAIR 基因的 rs874945 多态性观察到癌症风险增加。rs12427129 多态性仅在隐性模型中显示与癌症易感性相关。基于癌症类型的亚组分析表明，rs4759314多态性显着增加胃癌和宫颈癌的风险，rs920778多态性增加了胃肠道癌、宫颈癌和胃癌的风险。总之，本研究发现 HOTAIR 多态性与癌症发展显着相关。