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Novel synthesis of PVA/GA hydrogel microspheres based on microfluidic technology
Journal of Flow Chemistry ( IF 2.7 ) Pub Date : 2020-06-02 , DOI: 10.1007/s41981-020-00101-w
Dengyu Luo , Lin Guo , Yuan Wang , Pingping Wang , Zhenqi Chang

The hydrogel microspheres of polyvinyl alcohol (PVA)/ glutaraldehyde (GA) used as embolic agent can be applied in the embolization therapy. The mechanical properties and size precision of the hydrogel microspheres have a strong influence on its clinical application. In this work, the microfluidic technology was employed in the preparation of size-controlled PVA/GA hydrogel microspheres, and a novel in-situ gelation system was proposed. The influences of cross-linker (GA) content and the total content of PVA and GA in the dispersed phase, and catalyst content in the continuous phase on the compressive strength and deformation of PVA/GA gel microspheres were investigated in detail. Also, the kinetic behaviours of the formation of PVA/GA hydrogel microspheres in the microfluidic system were studied, and the results indicated that the gelation processes based on microfluidics accord to first-order reaction.



中文翻译:

基于微流控技术的新型PVA / GA水凝胶微球合成

用作栓塞剂的聚乙烯醇(PVA)/戊二醛(GA)的水凝胶微球可用于栓塞治疗。水凝胶微球的机械性能和尺寸精度对其临床应用有很大影响。在这项工作中,微流体技术被用于制备尺寸可控的PVA / GA水凝胶微球,并提出了一种新颖的原位凝胶化系统。详细研究了交联剂(GA)含量以及分散相中PVA和GA的总含量以及连续相中催化剂的含量对PVA / GA凝胶微球抗压强度和变形的影响。此外,还研究了在微流体系统中形成PVA / GA水凝胶微球的动力学行为,

更新日期:2020-06-02
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