Second only to brown rot caused by Monilinia spp., grey mould caused by Botrytis spp. is one of the most important pre- and post-harvest diseases of stone fruit in northern Germany. Among 484 Botrytis isolates from sweet cherries produced under integrated pest management (IPM), 60.3% showed resistance to QoI fungicides and 54.6% to boscalid, reflecting the heavy use of these compounds in regional production. More modest resistance frequencies were recorded for fenhexamid (20.7%), fluopyram (8.3%), fludioxonil (9.1%) and cyprodinil (21.9%). A 7.6% share of isolates possessed multiple resistance to at least five of these fungicides. Resistance was also detected for two fungicides no longer registered in cherries, viz. thiophanate-methyl (15.7%) and iprodione (20.9%). Similar results were obtained for 141 Botrytis isolates from IPM plum orchards. In contrast, in organically produced cherries (88 Botrytis isolates) resistance frequencies were < 20% for all fungicides. The dominant species on cherries and plums was B. cinerea. The share of B. pseudocinerea, which is not known to have developed resistance to commercial fungicides, was 18.0% in cherries and 9.9% in plums from IPM, but 50.0% in organically produced cherries. A 10-year annual survey of a sweet cherry orchard under IPM showed the immigration of multi-resistant B. cinerea strains in 2011, followed by their increase and decline in subsequent years. An understanding of the effects of fungicide spray regimes on Botrytis population dynamics in stone fruit has implications for resistance management. In practice, a limitation of the number of pre-harvest sprays to a maximum of two will give a satisfactory control of brown rot in most situations, while a higher number will promote multi-resistant B. cinerea strains.

仅次于Monilinia spp。引起的褐腐病，Botrytis spp引起的灰霉病。是德国北部核果最重要的收获前和收获后疾病之一。在484葡萄孢中在病虫害综合治理（IPM）下生产的甜樱桃分离物中，对QoI杀菌剂有抗性，对Boscalid的抗药性为60.3％，这反映了这些化合物在区域生产中的大量使用。苯六胺（20.7％），氟吡草（8.3％），氟地西尼（9.1％）和环丙地尼（21.9％）的耐性频率较低。7.6％的分离株对这些杀真菌剂中的至少五个具有多重抗性。还检测到不再在樱桃中登记的两种杀菌剂的抗性，即。甲基托布津（15.7％）和异丙洛酮（20.9％）。从IPM李子果园的141株葡萄孢分离株获得了相似的结果。相反，在有机樱桃中（88 Botrytis所有杀菌剂的抗性频率均<20％。樱桃和李子的优势种是灰葡萄孢。的份额B. pseudocinerea，这是不知道有商业杀菌剂产生抗药性，是樱桃18.0％，而从IPM李子9.9％，但在有机生产的樱桃50.0％。在IPM下对甜樱桃园进行的为期10年的年度调查显示，多重抗性灰葡萄孢菌株于2011年移民，随后几年又有所增加和减少。了解杀菌剂喷洒方式对葡萄孢属的影响核果中的种群动态对耐药性管理具有影响。实际上，在大多数情况下，将收获前喷雾的数量限制为最多两次将可以令人满意地控制褐腐病，而更高的数量将促进多重抗性的灰葡萄孢菌株。