Background

The unique ability of NK cells to target cancer cells without antigen specificity makes them an attractive prospect for immunotherapy of solid tumors. However, the complexity of the tumor microenvironment (TME), particularly its heterogeneity and associated immunosuppressive properties, enables solid tumor cells to escape NK cell immune-surveillance by impairing their infiltration and cytotoxic functions. As a result, NK cells that have been able to infiltrate solid tumors are dysfunctional, exhausted and metabolically and functionally impaired. Understanding the status of NK cells in solid tumors and the interplay between the tumor-promoting functions of the TME and the immunometabolic reprogramming events that NK cells endure as a result is essential to developing approaches to improve the clinical outcome of NK cell-based immunotherapies against solid tumors.

Conclusions

In this review, we address the current knowledge on the presence and immunometabolic roles of NK cells in solid tumors as well as the strategies developed to restore NK cell activities in these conditions, with the ultimate goal of enhancing persistence, trafficking, cytotoxicity and metabolic functions.

中文翻译：

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天然杀伤细胞针对实体瘤的功能和代谢靶向。

背景

NK细胞无抗原特异性地靶向癌细胞的独特能力使其成为用于实体瘤免疫治疗的诱人前景。但是，肿瘤微环境（TME）的复杂性，尤其是其异质性和相关的免疫抑制特性，使实体肿瘤细胞能够通过损害其浸润和细胞毒性功能而逃避NK细胞的免疫监视。结果，已经能够浸润实体瘤的NK细胞功能失调，精疲力竭，并且代谢和功能受损。

结论

在这篇综述中，我们讨论了有关实体瘤中NK细胞的存在和免疫代谢作用的最新知识，以及在这些情况下恢复NK细胞活性的发展战略，其最终目标是增强持久性，运输，细胞毒性和代谢功能。