Nanotechnology provides a great opportunity to design multifunctional materials that can be applied for diverse platforms. As a case study, we prepared bismuth oxychloride nanoplatelets (BiOCl–NPLs) and used as bifunctional interfaces to bind biomarkers, selectively, as well as their biocompatibility potential was assessed. The structures were prepared by a facile and efficiently designed hydrothermal method and possess layered nanoplatelets morphology. The phase composition was investigated by XRD which is in accordance with the tetragonal structure of BiOCl. EDS confirmed the surface elemental composition, whereas, FTIR analysis validated the molecular structure of the prepared structures. BiOCl–NPLs modified interfaces were found remarkable to bind glutathione, an important disease biomarker. The material showed a significant sensing response to bind glutathione, which highlights its diagnostic applications. And the biocompatibility is investigated towards the human colorectal carcinoma cell line (HCT 116) using MTT assay in vitro. Our results showed that BiOCl–NPLs are non-cytotoxic, an important feature for biomedical use. The present study leads a pathway to design dual-functional materials for diagnostic and clinical applications.

纳米技术为设计可应用于多种平台的多功能材料提供了绝佳机会。作为案例研究，我们制备了氯氧化铋纳米血小板（BiOCl–NPL），并用作双功能界面来选择性结合生物标记，并评估了它们的生物相容性。该结构是通过一种简便且有效设计的水热方法制备的，并具有层状纳米片形态。通过XRD研究相组成，其与BiOCl的四方结构一致。EDS证实了表面元素的组成，而FTIR分析证实了所制备结构的分子结构。发现BiOCl–NPLs修饰的界面与谷胱甘肽（一种重要的疾病生物标记物）结合显着。该材料对结合谷胱甘肽显示出显着的传感反应，这突出了其诊断应用。并利用MTT法体外研究了对人结肠直肠癌细胞系（HCT 116）的生物相容性。我们的结果表明，BiOCl–NPL不具细胞毒性，是生物医学用途的重要特征。本研究引领了设计用于诊断和临床应用的双功能材料的途径。