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Response to Brandt, Bednarz-Knoll, Kleinheinz et al.
Journal of the National Cancer Institute ( IF 10.3 ) Pub Date : 2020-07-05 , DOI: 10.1093/jnci/djaa075
Anil K Chaturvedi 1 , Natalia Udaltsova 2 , Eric A Engels 1 , Jed A Katzel 2 , Elizabeth L Yanik 3 , Hormuzd A Katki 1 , Mark W Lingen 4 , Michael J Silverberg 5
Affiliation  

We thank Brandt and colleagues for their interest in our article. In a population-based study of oral leukoplakia and risk of progression to oral cancer, we reported that the decision to biopsy a leukoplakia had modest predictive ability for the identification of prevalent or incident oral cancers (sensitivity of 59.6%, specificity of 62.1%, and positive predictive value [PPV] of 5.1%). Furthermore, although grade of dysplasia was statistically significantly associated with risk of progression to cancer, a high proportion of oral cancers (39.6%) arose from leukoplakias without evidence of dysplasia. We concluded that our results underscore the need for tools to improve triage and reduce sampling errors of the biopsy of oral leukoplakia.

中文翻译:

对勃兰特,贝德纳兹·诺尔,克莱因海因茨等人的回应。

感谢Brandt和同事对我们的文章感兴趣。在一项基于人群的口腔白斑和发展为口腔癌的风险的研究中,我们报告说,对白斑进行活检的决定对于识别流行或意外口腔癌具有中等预测能力(敏感性为59.6%,特异性为62.1%,阳性预测值[PPV]为5.1%)。此外,尽管不典型增生的程度与发展为癌症的风险在统计学上显着相关,但是在没有明显不典型增生迹象的情况下,高比例的口腔癌(39.6%)是由白斑引起的。我们得出的结论是,我们的结果强调了需要使用工具来改善口腔白斑活检的分类和减少抽样错误。
更新日期:2020-07-05
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