Abstract

The current investigation was accomplished to evaluate the hepatoprotective effect of White tea and Raspberry Ketone against toxicity induced by acrylamide in rats. Sixty adult male rats were divided randomly into group (I) control; group (II) rats received RK with dose (6 mg/kg/day); Group III: rats received 5 ml of WT extract/kg/day; Group IV rats received AA (5 mg/kg/day); Group V: rats administrated with both AA (5 mg/kg/day) and RK (6 mg/kg/day) and Group VI: rats administrated AA (5 mg/kg/day) and 5 ml of WT extract/kg/day. The biochemical assays exhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI. The histopathological and immunohistochemical findings confirm the biochemical observations. In conclusion, the present investigation proved that the supplementation of WT and RK enhanced the liver histology, immunohistochemistry and biochemistry against the oxidative stress induced by acrylamide.

摘要

目前的研究是为了评估白茶和覆盆子酮对丙烯酰胺引起的大鼠毒性的保肝作用。将60只成年雄性大鼠随机分为(I)组对照组；(II)组大鼠接受剂量(6mg/kg/天)的RK；第三组：大鼠接受 5 ml WT 提取物/kg/天；IV组大鼠接受AA（5mg/kg/天）；第 V 组：给予大鼠 AA（5 mg/kg/天）和 RK（6 mg/kg/天）和第 VI 组：大鼠给予 AA（5 mg/kg/天）和 5 ml WT 提取物/kg/日。生化测定显示，与对照组相比，用丙烯酰胺处理的组的脂联素、AST、ALT、ALP的血清水平显着增加，并且其V组和VI组的水平有所改善。组织病理学和免疫组织化学结果证实了生化观察结果。