Abstract Copper-67 (67Cu), a feasible radionuclide for diagnosis and radiotherapy, is commercially generated from a bulk zinc (Zn) target using the 68Zn(p, 2p)67Cu and 68Zn(γ, p)67Cu nuclear reactions. Because it uses a large amount of zinc, the separation is complex – requiring a combination of three ion exchange columns – and is time-consuming (about 1 day). We developed a quick and easy separation method referred to as “double coprecipitation” using H2S gas and silver nitrate as coprecipitation agents in place of ion exchange columns. We compared this method with a conventional separation method using three ion exchange columns (AG50W-X8, AG1-X8, and Chelex-100) for a natural zinc (natZn) target irradiated by a proton beam. The product quality and the recovery rate with the new method were competitive with the conventional method, and the total operation time was reduced from 1 day to <3 h.

中文翻译：

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使用硫化氢气体和硝酸银通过共沉淀法从块状锌中简单分离 67Cu

摘要 铜 67 (67Cu) 是一种用于诊断和放射治疗的可行放射性核素，它是使用 68Zn(p, 2p)67Cu 和 68Zn(γ, p)67Cu 核反应从块状锌 (Zn) 靶材商业化生产的。因为它使用了大量的锌，所以分离很复杂——需要三个离子交换柱的组合——并且很耗时（大约 1 天）。我们开发了一种快速简便的分离方法，称为“双共沉淀”，使用 H2S 气体和硝酸银作为共沉淀剂代替离子交换柱。我们将这种方法与使用三个离子交换柱（AG50W-X8、AG1-X8 和 Chelex-100）的传统分离方法进行了比较，用于质子束照射的天然锌 (natZn) 靶。新方法的产品质量和回收率与常规方法相比具有竞争力，