Abstract The study aims to examine the risk factors for increased colorectal cancer (CRC) markers in patients with type 2 diabetes mellitus (T2DM). The 229 patients retrospectively reviewed were categorized into two groups: CRC tumor marker-positive and -negative groups. Patients who tested positive for all three of the following CRC markers were included in the CRC tumor marker-positive group: serum carcinoembryonic antigen, carbohydrate antigen 19-9 and septin9 methylation. Univariate analysis revealed that most CRC marker-positive patients had higher age, a family history of CRC, history of smoking and alcohol intake, high body mass index (BMI; overweight), longer history of T2DM, worse diabetes control (with high glycated hemoglobin A1c [HbA1c]), lower level of serum vitamin D (VD), high-density lipoprotein cholesterol and higher level of total cholesterol and triglyceride (TG). Logistic regression analysis showed that BMI, VD, HbA1c and TG were independent predictors of CRC marker-positive status (OR, 95% confidence intervals and P values were 1.912 [1.346–2.716], <0.001; 0.773 [0.633–0.943], 0.011; 9.082 [3.52–23.433], <0.001; and 11.597 [3.267–41.164], <0.001, respectively). In this retrospective study, high BMI, HbA1c and TG as well as low level of VD were correlated with CRC tumor marker-positive status in T2DM patients. Patients with these risk factors may benefit from more frequent screening for CRC tumor markers.

中文翻译：

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2型糖尿病患者血清大肠癌标志物升高的危险因素

摘要 本研究旨在检查 2 型糖尿病 (T2DM) 患者结直肠癌 (CRC) 标志物升高的危险因素。回顾性审查的 229 名患者分为两组：CRC 肿瘤标志物阳性组和阴性组。以下所有三种 CRC 标志物检测呈阳性的患者被包括在 CRC 肿瘤标志物阳性组中：血清癌胚抗原、碳水化合物抗原 19-9 和 septin9 甲基化。单变量分析显示，大多数 CRC 标志物阳性患者年龄较大、有 CRC 家族史、吸烟和饮酒史、高体重指数（BMI；超重）、较长的 T2DM 病史、较差的糖尿病控制（高糖化血红蛋白） A1c [HbA1c])，血清维生素 D (VD) 水平较低，高密度脂蛋白胆固醇和较高水平的总胆固醇和甘油三酯 (TG)。Logistic 回归分析显示 BMI、VD、HbA1c 和 TG 是 CRC 标志物阳性状态的独立预测因子（OR，95% 置信区间和 P 值为 1.912 [1.346–2.716]，<0.001；0.773 [0.633–0.943]，0.011 ；分别为 9.082 [3.52–23.433]，<0.001；和 11.597 [3.267–41.164]，<0.001）。在这项回顾性研究中，高 BMI、HbA1c 和 TG 以及低水平的 VD 与 T2DM 患者的 CRC 肿瘤标志物阳性状态相关。具有这些危险因素的患者可能会受益于更频繁的 CRC 肿瘤标志物筛查。95% 置信区间和 P 值为 1.912 [1.346–2.716]，<0.001；0.773 [0.633–0.943], 0.011; 9.082 [3.52–23.433]，<0.001；和 11.597 [3.267–41.164]，分别<0.001）。在这项回顾性研究中，高 BMI、HbA1c 和 TG 以及低水平的 VD 与 T2DM 患者的 CRC 肿瘤标志物阳性状态相关。具有这些危险因素的患者可能会受益于更频繁的 CRC 肿瘤标志物筛查。95% 置信区间和 P 值为 1.912 [1.346–2.716]，<0.001；0.773 [0.633–0.943], 0.011; 9.082 [3.52–23.433]，<0.001；和 11.597 [3.267–41.164]，分别<0.001）。在这项回顾性研究中，高 BMI、HbA1c 和 TG 以及低水平的 VD 与 T2DM 患者的 CRC 肿瘤标志物阳性状态相关。具有这些危险因素的患者可能会受益于更频繁的 CRC 肿瘤标志物筛查。