Abstract Introduction Fowl adenovirus can cause important diseases in chickens such as inclusion body hepatitis, hepatitis hydropericardium syndrome, and gizzard erosion and ulceration. Inclusion body hepatitis has been regularly reported from many countries. This is the first case report from Turkey, describing an outbreak of inclusion body hepatitis in broiler farms due to fowl adenovirus-8b (FAdV-8b). Material and Methods Broiler flocks with mortality about 10% were visited in Turkey, and necropsy was performed on dead birds. Samples were subjected to PCR assay to detect FAdV and other viral pathogens. After sequencing, phylogenetic analysis was performed and the nucleotide sequences of hexon genes were compared with the FAdV sequences data available in GenBank. Results Clinical signs such as anorexia, depression, ruffled feathers, huddling, and greenish diarrhoea were observed. Mortality started at the 8th day of age and ranged from 10% to 14%. Necropsy showed severe hepatitis, jaundice, and pancreatitis. The main necropsy findings included a pale, enlarged, haemorrhagic, and friable liver along with swollen and haemorrhagic kidneys and spleen. PCR and sequence analysis revealed the presence of fowl adenovirus serotype 8b (FAdV-E). Conclusion This is the first report on characterisation and the pathological lesions associated with FAdV in broilers in Turkey. Our findings suggest that FAdV strains could be an emerging pathogen in Turkish broilers and could actively contribute to hepatitis and immunosuppression.

中文翻译：

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鸡腺病毒（FAdV-8b）株的特征与土耳其肉鸡包涵体肝炎相关的地理分析和病理损伤

摘要 引言 鸡腺病毒可引起鸡包涵体肝炎、肝炎心包积水综合征、肌腱糜烂和溃疡等重要疾病。许多国家经常报告包涵体肝炎。这是土耳其的首例病例报告，描述了肉鸡场因家禽腺病毒 8b (FAdV-8b) 爆发包涵体肝炎。材料和方法 在土耳其参观了死亡率约为 10% 的肉鸡群，并对死鸡进行了尸检。对样品进行 PCR 检测以检测 FAdV 和其他病毒病原体。测序后，进行系统发育分析，并将六邻体基因的核苷酸序列与 GenBank 中可用的 FAdV 序列数据进行比较。结果 临床症状，如厌食、抑郁、羽毛皱褶、蜷缩、并观察到绿色腹泻。死亡率从第 8 天开始，范围从 10% 到 14%。尸检显示有严重的肝炎、黄疸和胰腺炎。主要的尸检结果包括苍白、扩大、出血和脆弱的肝脏，以及肿胀和出血的肾脏和脾脏。PCR 和序列分析揭示了禽腺病毒血清型 8b (FAdV-E) 的存在。结论 这是土耳其肉鸡 FAdV 相关特征和病理损伤的第一份报告。我们的研究结果表明，FAdV 菌株可能是土耳其肉鸡中的一种新兴病原体，并可能对肝炎和免疫抑制产生积极影响。主要的尸检结果包括苍白、扩大、出血和脆弱的肝脏，以及肿胀和出血的肾脏和脾脏。PCR 和序列分析揭示了禽腺病毒血清型 8b (FAdV-E) 的存在。结论 这是土耳其肉鸡 FAdV 相关特征和病理损伤的第一份报告。我们的研究结果表明，FAdV 菌株可能是土耳其肉鸡中的一种新兴病原体，并可能对肝炎和免疫抑制产生积极影响。主要的尸检结果包括苍白、扩大、出血和脆弱的肝脏，以及肿胀和出血的肾脏和脾脏。PCR 和序列分析揭示了禽腺病毒血清型 8b (FAdV-E) 的存在。结论 这是土耳其肉鸡 FAdV 相关特征和病理损伤的第一份报告。我们的研究结果表明，FAdV 菌株可能是土耳其肉鸡中的一种新兴病原体，并可能对肝炎和免疫抑制产生积极影响。结论 这是土耳其肉鸡 FAdV 相关特征和病理损伤的第一份报告。我们的研究结果表明，FAdV 菌株可能是土耳其肉鸡中的一种新兴病原体，并可能对肝炎和免疫抑制产生积极影响。结论 这是土耳其肉鸡 FAdV 相关特征和病理损伤的第一份报告。我们的研究结果表明，FAdV 菌株可能是土耳其肉鸡中的一种新兴病原体，并可能对肝炎和免疫抑制产生积极影响。