Abstract Tubular fibers (raw and wax-free) from Ceiba pentandra (CP) were cross-linked with butane-1,2,3,4-tetracarboxylic acid (BTCA) at different concentrations to obtain a porous biodegradable medium for drug release applications. Chlorhexidine diacetate (CHX) was added to the cross-linked fibers for drug release studies. The Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy results indicated that the cross-linked fibers with a 5:1 fiber:BTCA ratio presented the higher cross-linking density. CHX was added at different concentrations (8% and 16% wt/wt); the elemental analysis indicated that CHX was loaded up to 7.99 wt%. In vitro studies showed a burst release of CHX within the first 3 h. CHX release kinetics was described using several models, with the Korsmeyer–Peppas equation, which adjusted better to the experimental data. The results indicated that the CP fibers are a feasible material for drug release applications.

中文翻译：

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用于药物释放应用的 Ceiba pentandra 纤维素的改性

摘要 Ceiba pentandra (CP) 的管状纤维（未加工和无蜡）与不同浓度的丁烷-1,2,3,4-四羧酸（BTCA）交联，以获得用于药物释放应用的多孔生物可降解介质。将二乙酸氯己定 (CHX) 添加到交联纤维中用于药物释放研究。傅里叶变换红外光谱、热重分析和扫描电子显微镜结果表明，纤维：BTCA 比例为 5:1 的交联纤维表现出较高的交联密度。CHX 以不同浓度（8% 和 16% wt/wt）加入；元素分析表明 CHX 的负载量高达 7.99 wt%。体外研究表明 CHX 在前 3 小时内突然释放。CHX 释放动力学使用多种模型描述，Korsmeyer-Peppas 方程，更好地适应了实验数据。结果表明，CP 纤维是一种适用于药物释放应用的可行材料。