当前位置:
X-MOL 学术
›
Pharmaceutics
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine.
Pharmaceutics ( IF 5.4 ) Pub Date : 2020-06-02 , DOI: 10.3390/pharmaceutics12060504 Jake G Edmans 1, 2 , Katharina H Clitherow 1, 2 , Craig Murdoch 1 , Paul V Hatton 1 , Sebastian G Spain 2 , Helen E Colley 1
Pharmaceutics ( IF 5.4 ) Pub Date : 2020-06-02 , DOI: 10.3390/pharmaceutics12060504 Jake G Edmans 1, 2 , Katharina H Clitherow 1, 2 , Craig Murdoch 1 , Paul V Hatton 1 , Sebastian G Spain 2 , Helen E Colley 1
Affiliation
Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future.
中文翻译:
用于口腔医学的粘膜粘着静电纺丝技术。
口腔疾病极大地影响了生活质量,因为口语是包括语音,食物和液体消耗在内的各种活动所必需的。口腔疾病的治疗受到目前可用的剂型的极大限制,这些剂型具有接触时间短,位点特异性差和对机械刺激的敏感性。通过静电纺丝制备的粘膜粘着剂设备通过与粘膜紧密接触并以高表面积促进药物释放,实现了单向特定部位的药物递送,从而有可能解决这些挑战。这篇评论将讨论最近被报道用于解决口腔炎性疾病,缓解疼痛和感染的电纺粘膜粘附设备的范围,以及将来可能由该技术实现的新疗法。
更新日期:2020-06-02
中文翻译:
用于口腔医学的粘膜粘着静电纺丝技术。
口腔疾病极大地影响了生活质量,因为口语是包括语音,食物和液体消耗在内的各种活动所必需的。口腔疾病的治疗受到目前可用的剂型的极大限制,这些剂型具有接触时间短,位点特异性差和对机械刺激的敏感性。通过静电纺丝制备的粘膜粘着剂设备通过与粘膜紧密接触并以高表面积促进药物释放,实现了单向特定部位的药物递送,从而有可能解决这些挑战。这篇评论将讨论最近被报道用于解决口腔炎性疾病,缓解疼痛和感染的电纺粘膜粘附设备的范围,以及将来可能由该技术实现的新疗法。