Psoriasis (PS) and atopic dermatitis (AD) are common inflammatory skin diseases characterized by an imbalance in specific T‐cell subsets, resulting in a specific cytokine profile in patients. Obtaining models closely resembling both pathologies along with a relevant clinical impact is crucial for the development of new therapies because of the high prevalence of these diseases. Single‐gene mouse models developed until now do not fully reflect the complexity of these disorders, in part not only because of inherent differences between mice and humans but also because of the multifactorial nature of these pathologies. The skin‐humanized mouse model developed by our group, based on a tissue engineering approach, has been used to test therapeutic strategies, although this methodology is still technically challenging and not widely available. The skin‐humanized mouse models for PS and AD reproduce human skin phenotypes, providing valuable tools for drug development and testing in the preclinical setting. The tissue engineering approach allows the development of personalized medicine, covering the broad genotypic spectrum of these pathologies. This review highlights the main differences between available murine models focusing on the tissue‐specific immunity of PS and AD. We discuss their contribution to unravel the complex pathophysiology of these diseases and to translate this knowledge into more accurate therapies.

中文翻译：

---

免疫在开发可靠的银屑病和特应性皮炎动物模型中的重要性。

银屑病 (PS) 和特应性皮炎 (AD) 是常见的炎症性皮肤病，其特征是特定 T 细胞亚群的失衡，导致患者出现特定的细胞因子谱。由于这些疾病的高患病率，获得与这两种病理学非常相似的模型以及相关的临床影响对于新疗法的开发至关重要。迄今为止开发的单基因小鼠模型并不能完全反映这些疾病的复杂性，部分原因不仅是因为小鼠和人类之间的内在差异，还因为这些病理的多因素性质。我们小组基于组织工程方法开发的皮肤人源化小鼠模型已被用于测试治疗策略，尽管这种方法在技术上仍然具有挑战性且未广泛使用。PS 和 AD 的皮肤人源化小鼠模型再现了人类皮肤表型，为临床前环境中的药物开发和测试提供了宝贵的工具。组织工程方法允许开发个性化医疗，涵盖这些病理的广泛基因型谱。这篇综述强调了现有小鼠模型之间的主要差异，重点是 PS 和 AD 的组织特异性免疫。我们讨论了他们对解开这些疾病的复杂病理生理学并将这些知识转化为更准确的治疗方法的贡献。涵盖了这些病理的广泛基因型谱。这篇综述强调了现有小鼠模型之间的主要差异，重点是 PS 和 AD 的组织特异性免疫。我们讨论了他们对解开这些疾病的复杂病理生理学并将这些知识转化为更准确的治疗方法的贡献。涵盖了这些病理的广泛基因型谱。这篇综述强调了现有小鼠模型之间的主要差异，重点是 PS 和 AD 的组织特异性免疫。我们讨论了他们对解开这些疾病的复杂病理生理学并将这些知识转化为更准确的治疗方法的贡献。