We herein report the first example of iridium‐catalyzed enantioselective C(sp³)–H borylation of cyclobutanes using benzoxazoline as the directing group. The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp³)–H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities. We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.

中文翻译：

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铱催化的环戊二烯对映选择性C（sp3）–H硼化

我们在此报告了使用苯并恶唑啉作为导向基团的铱催化环丁烷对映选择性C（sp ³）-H硼化的第一个例子。已发现手性双齿硼烷基配体和铱前体的组合可有效催化C（sp ³）-H硼化反应，从而提供具有良好至优异对映选择性的各种环丁基硼酸酯。通过将立体成因的C-B键转换为其他功能，我们还证明了当前方法的合成效用。