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Effects of high fructose corn syrup on ethanol self-administration in rats.
Alcohol ( IF 2.3 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.alcohol.2020.05.003
Samantha M Ayoub 1 , Meenu Minhas 1 , Thomas Lapointe 1 , Cheryl L Limebeer 1 , Linda A Parker 1 , Francesco Leri 1
Affiliation  

Objective

The addition of sweeteners to alcoholic beverages is thought to facilitate heavy alcohol consumption, and this may be of particular concern when the additive is high fructose corn syrup (HFCS).

Methods

Four experiments in male Sprague-Dawley rats were performed to investigate whether the addition of 25% HFCS to ethanol (5%, 10%, and 20% v/v ethanol) would alter its intraoral operant self-administration, palatability, and sensitivity to food deprivation stress.

Results

As anticipated, HFCS drastically increased ethanol intake, and this effect appeared driven by its caloric value. Importantly, HFCS increased the persistence of operant responding following extinction in animals trained to self-administer the combination, and the addition of HFCS to ethanol changed subsequent responses to ethanol, including increased palatability and intake.

Conclusions

These results in rats suggest that the addition of HFCS to the list of ingredients in sweetened alcoholic beverages could play a significant role in the harmful consumption of ethanol-containing beverages.



中文翻译:

高果糖玉米糖浆对大鼠乙醇自我给药的影响。

客观的

在酒精饮料中添加甜味剂被认为会促进大量饮酒,当添加剂是高果糖玉米糖浆 (HFCS) 时,这可能会引起特别关注。

方法

在雄性 Sprague-Dawley 大鼠中进行了四项实验,以研究向乙醇(5%、10% 和 20% v/v 乙醇)中添加 25% HFCS 是否会改变其口内操作性自我给药、适口性和敏感性食物剥夺压力。

结果

正如预期的那样,HFCS 大大增加了乙醇的摄入量,这种效果似乎是由其热量值驱动的。重要的是,HFCS 增加了经过训练以自我给药组合的动物在灭绝后操作性反应的持续性,并且将 HFCS 添加到乙醇中改变了对乙醇的后续反应,包括增加的适口性和摄入量。

结论

大鼠的这些结果表明,在含糖酒精饮料的成分列表中添加 HFCS 可能在有害消费含乙醇饮料方面发挥重要作用。

更新日期:2020-07-18
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