Therapeutic approaches to decrease serum triglyceride (TG) concentrations are not successful mainly due to poor adherence or adverse effects of therapies. In consequence, the search for new low-cost and safer therapeutic alternatives is mandatory. Dark chocolate and cacao have shown promising results improving lipid profiles. Recently, using cacao by-products to reduce elevated cardiometabolic risk markers in an animal model of obesity induced by a high-fat diet and fructose, we showed that TGs, low-density lipoprotein cholesterol, and the TG/high-density lipoprotein (HDL) ratio decreased, suggesting that cacao by-products improved the metabolic function of obese animals. Based on these results, as a proof of concept, a blinded placebo-controlled study was implemented to explore the effects of cacao by-products on anthropometric and biochemical variables in a group of overweight subjects participating in a program composed of reduced-calorie-diet counseling plus a simple aerobic exercise plan. The results showed that counseling induced weight and abdominal circumference reductions in both groups. TGs did not change in the control group; however, TG decreased significantly by 54.9 mg/dL (27.9%) in the experimental group. The TG/HDL cholesterol ratio changed markedly (1.5) in the experimental group. The results reported suggest the use of cacao by-products as an alternative for the treatment of hypertriglyceridemia.

中文翻译：

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可可副产品和适度的减肥干预对超重受试者血清甘油三酸酯浓度的影响：概念验证。

降低血清甘油三酯（TG）浓度的治疗方法并不成功，主要是因为依从性差或治疗的不良影响。因此，必须寻求新的低成本和更安全的治疗选择。黑巧克力和可可已显示出改善脂质分布的有希望的结果。最近，在高脂饮食和果糖诱发的肥胖动物模型中，使用可可副产品减少升高的心脏代谢风险标志物，我们发现了TG，低密度脂蛋白胆固醇和TG /高密度脂蛋白（HDL） ）比率降低，表明可可副产物改善了肥胖动物的代谢功能。根据这些结果，作为概念证明，进行了一项盲目的安慰剂对照研究，以探讨可卡因副产物对一组超重受试者的人体测量学和生化变量的影响，该受试者参加了由减少卡路里饮食咨询和简单的有氧运动计划组成的计划。结果表明，咨询可减轻两组患者的体重和腹围。对照组的TG没有变化；然而，实验组的TG显着下降了54.9 mg / dL（27.9％）。在实验组中，TG / HDL胆固醇比率发生了显着变化（1.5）。报告的结果表明，可可副产品可替代高甘油三酯血症的治疗方法。结果表明，咨询可减轻两组患者的体重和腹围。对照组的TG没有变化；然而，实验组的TG显着下降了54.9 mg / dL（27.9％）。在实验组中，TG / HDL胆固醇比率发生了显着变化（1.5）。报告的结果表明，可可副产品可替代高甘油三酯血症的治疗方法。结果表明，咨询可减轻两组患者的体重和腹围。对照组的TG没有变化；然而，实验组的TG显着下降了54.9 mg / dL（27.9％）。在实验组中，TG / HDL胆固醇比率发生了显着变化（1.5）。报告的结果表明，可可副产品可替代高甘油三酯血症的治疗方法。