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Antimicrobial Resistance of Campylobacter in Broiler Chicken Along the Food Chain in Canada.
Foodborne Pathogens and Disease ( IF 2.8 ) Pub Date : 2020-08-06 , DOI: 10.1089/fpd.2019.2752
Ousmane Dramé 1, 2 , Daniel Leclair 1 , E Jane Parmley 3 , Anne Deckert 3 , Blaise Ouattara 1 , Danielle Daignault 4 , André Ravel 2
Affiliation  

Antimicrobial resistance (AMR) is a major public health threat worldwide. The main objective of this study was to compare AMR in Campylobacter from broiler chickens raised on Canadian farms and their products in different geographical regions of Canada. To do this, antimicrobial susceptibility results from isolates of Campylobacter recovered from a national microbiological baseline study conducted in federally registered establishments and in the retail marketplace were analyzed. Among 1460 isolates tested, 774 (53%) were resistant to at least one antimicrobial, with a predominance of three profiles: tetracycline (39%), quinolone–tetracycline (6.6%), and quinolones only (3.5%). The results showed no significant difference in the frequency of resistant profiles (p ≥ 0.05) among the isolates originating from different points in the food processing chain at slaughterhouses and in retail establishments. This suggests that AMR observed in Campylobacter isolates from raw chicken at retail originated further upstream in the system. A difference in the frequency of certain resistance profiles was observed between the regions of Canada. For instance, in British Columbia, there was more resistance to quinolones, while in Ontario and Quebec, Campylobacter isolates were more resistant to tetracyclines, macrolides, ketolides, and lincosamides. Comparison of AMR data from this study with those from the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) did not show any significant difference and provides evidence that CIPARS produces nationally representative resistance results.

中文翻译:

加拿大食物链中肉鸡弯曲杆菌的抗菌耐药性。

抗菌素耐药性(AMR)是全球主要的公共卫生威胁。本研究的主要目的是比较加拿大农场饲养的肉鸡及其在加拿大不同地理区域的产品中弯曲杆菌的抗菌素耐药性。为此,对在联邦注册机构和零售市场进行的国家微生物学基线研究中回收的弯曲杆菌分离株的抗菌敏感性结果进行了分析。在测试的 1460 株分离株中,774 株(53%)对至少一种抗菌药物具有耐药性,其中三种耐药菌株占主导地位:四环素(39%)、喹诺酮-四环素(6.6%)和仅喹诺酮类药物(3.5%)。结果显示, 来自屠宰场和零售场所食品加工链不同环节的菌株的耐药谱频率没有显着差异( p ≥ 0.05)。这表明在零售生鸡肉中分离出的弯曲杆菌中观察到的 AMR起源于系统的更上游。在加拿大各地区之间观察到某些电阻曲线的频率存在差异。例如,在不列颠哥伦比亚省,对喹诺酮类药物的耐药性更强,而在安大略省和魁北克省,弯曲杆菌分离株对四环素类、大环内酯类、酮内酯类和林可酰胺类的耐药性更强。本研究的 AMR 数据与加拿大抗菌素耐药性监测综合计划 (CIPARS) 的数据进行比较,没有显示出任何显着差异,并提供了 CIPAR 产生全国代表性耐药性结果的证据。
更新日期:2020-08-12
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