This article reports the effect of ginsenoside Rb1 on some properties, morphology, and the drug release process of the chitosan (CS)/alginate (AG)/lovastatin (LOV) composite films prepared by a solution method using different contents of ginsenoside Rb1. The ratio of AG/CS was fixed at 4/1 (wt.%/wt.%), the content of LOV was 10 wt.%, and the content of ginsenoside Rb1 was changed from 1 to 5 wt.%. The results of scanning electron microscopy and Fourier transform infrared spectroscopy analysis showed that the composite films have a heterogeneous structure and the ginsenoside Rb1 content influenced on the structure of composite films. The presence of ginsenoside Rb1 did not influence on the melting temperature of these films but caused a significant difference in the melting enthalpy of the films. The ginsenoside Rb1 was also contributed positively on the LOV release from these films in different pH buffer solutions. The LOV release process from these films included two stages (fast/burst release and slow/control release). It was increased remarkably by the synergic effect of LOV and ginsenoside Rb1 in the drug release process. From the obtained results, we suggested that ginsenoside Rb1 plays an important role not only in the enhancement of health and immunity as general but also as an efficient agent in control of the LOV size as well as LOV drug release from the composite films.

中文翻译：

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人参皂苷RB1活性物质在藻酸盐/壳聚糖/洛伐他汀复合膜中的作用评估

本文报道了人参皂苷Rb1对通过溶液法制备的壳聚糖（CS）/藻酸盐（AG）/洛伐他汀（LOV）复合膜使用不同含量的人参皂苷Rb1的某些性质，形态和药物释放过程的影响。AG / CS的比率固定为4/1（重量％/重量％），LOV的含量为10重量％，人参皂苷Rb1的含量从1变为5重量％。扫描电子显微镜和傅立叶变换红外光谱分析结果表明，复合膜具有异质结构，人参皂苷Rb1含量对复合膜结构有影响。人参皂苷Rb1的存在不会影响这些薄膜的熔融温度，但会导致薄膜的熔融焓显着不同。人参皂苷Rb1在不同pH缓冲液中对这些薄膜的LOV释放也有积极贡献。这些胶片的LOV释放过程包括两个阶段（快速/爆发释放和缓慢/控制释放）。在药物释放过程中，LOV和人参皂苷Rb1的协同作用显着提高了它的活性。根据获得的结果，我们认为人参皂苷Rb1不仅在增强健康和免疫方面起着重要作用，而且在控制LOV大小以及从复合膜中释放LOV药物方面也起着有效的作用。在药物释放过程中，LOV和人参皂苷Rb1的协同作用显着提高了它的活性。根据获得的结果，我们认为人参皂苷Rb1不仅在增强健康和免疫方面起着重要作用，而且在控制LOV大小以及从复合膜中释放LOV药物方面也起着有效的作用。在药物释放过程中，LOV和人参皂苷Rb1的协同作用显着提高了它的活性。根据获得的结果，我们认为人参皂苷Rb1不仅在增强健康和免疫方面起着重要作用，而且在控制LOV大小以及从复合膜中释放LOV药物方面也起着有效的作用。