In this study, 5-fluorouracil- (5-FU-) loaded hydroxyapatite-gelatin (HAp-GEL) polymer composites were produced in the presence of a simulated body fluid (SBF) to investigate the effects of temperature and cross-linking agents on drug release. The composites were produced by wet precipitation at pH 7.4 and temperature 37°C using glutaraldehyde (GA) as the cross-linker. The effects of different amounts of glutaraldehyde on drug release profiles were studied. Encapsulation (drug loading) was performed with 5-FU using a spray drier, and the drug release of 5-FU from the HAp-GEL composites was determined at temperatures of 32°C, 37°C, and 42°C. Different mathematical models were used to obtain the release mechanism of the drug. The morphologies and structures of the composites were analyzed by X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy. The results demonstrated that for the HAp-GEL composites, the initial burst decreased with increasing GA content at all three studied temperatures. Further, three kinetic models were investigated, and it was determined that all the composites best fit the Higuchi model. It was concluded that the drug-loaded HAp-GEL composites have the potential to be used in drug delivery applications.

中文翻译：

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温度对药物释放的影响：通过喷雾干燥制备5-FU封装的羟基磷灰石-明胶聚合物复合材料和体外动力学分析

在这项研究中，在模拟体液（SBF）存在下制备了负载有5-氟尿嘧啶-（5-FU-）的羟基磷灰石-明胶（HAp-GEL）聚合物复合材料，以研究温度和交联剂对药物释放。使用戊二醛（GA）作为交联剂，通过在pH 7.4和37°C的温度下湿法沉淀制备复合材料。研究了不同量的戊二醛对药物释放曲线的影响。使用喷雾干燥器用5-FU进行封装（载药），并在32°C，37°C和42°C的温度下确定5-FU从HAp-GEL复合材料中的释放。使用不同的数学模型来获得药物的释放机理。复合材料的形貌和结构通过X射线衍射，热重分析，傅立叶变换红外光谱和扫描电子显微镜。结果表明，对于HAp-GEL复合材料，在所有三个研究温度下，初始爆破都随着GA含量的增加而降低。此外，研究了三个动力学模型，并确定所有复合材料最适合Higuchi模型。结论是载有药物的HAp-GEL复合材料具有在药物递送应用中使用的潜力。