Supplemental Digital Content is Available in the Text. This article describes novel methods of applying the Ages and Stages Questionnaire—3rd edition (ASQ-3) to assess and quantify developmental delay among children following the 2015–2016 Zika virus outbreak in Brazil. Many of the children with Zika virus infection were expected to have severe developmental delay. However, administering the ASQ-3 to caregivers of these children according to standard protocol would have screened for the overall presence of delay but not the severity of delay. We adopted an amended protocol for administration of the ASQ-3 to quantify the developmental functioning of children severely affected by Zika virus infection in this investigation. Protocols for administering the ASQ-3 among this population were drafted in consultation with developmental measurement experts and are presented here. Specific developmental estimates are discussed, including developmental age equivalents, developmental quotients, and developmental quotient z scores. The calculations of these estimates are presented with examples in the context of the 2015–2016 Zika virus outbreak and associated microcephaly among prenatally infected children from 2 states in northeastern Brazil. Potential applications of these methods for estimating developmental ability among similar pediatric populations are discussed.

中文翻译：

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调整年龄和阶段问卷以识别和量化有寨卡病毒感染证据的儿童的发育

补充数字内容在文本中可用。本文介绍了应用年龄和阶段问卷第 3 版 (ASQ-3) 来评估和量化 2015-2016 年巴西寨卡病毒爆发后儿童发育迟缓的新方法。许多感染寨卡病毒的儿童预计会出现严重的发育迟缓。然而，根据标准方案对这些儿童的照顾者进行 ASQ-3 筛查将筛查延迟的整体存在，而不是延迟的严重程度。在本次调查中，我们采用了修订后的 ASQ-3 管理方案，以量化受寨卡病毒感染严重影响的儿童的发育功能。在此人群中管理 ASQ-3 的协议是在与发育测量专家协商后起草的，并在此处介绍。讨论了具体的发育估计，包括发育年龄当量、发育商数和发育商 z 分数。这些估计值的计算以 2015-2016 年寨卡病毒爆发和来自巴西东北部 2 个州的产前感染儿童的相关小头畸形为例。讨论了这些方法在类似儿科人群中估计发育能力的潜在应用。这些估计值的计算以 2015-2016 年寨卡病毒爆发和来自巴西东北部 2 个州的产前感染儿童的相关小头畸形为例。讨论了这些方法在类似儿科人群中估计发育能力的潜在应用。这些估计值的计算以 2015-2016 年寨卡病毒爆发和来自巴西东北部 2 个州的产前感染儿童的相关小头畸形为例。讨论了这些方法在类似儿科人群中估计发育能力的潜在应用。