Positron emission tomography (PET) has been used for dose verification in charged particle therapy. The causes of washout of positron emitters by physiological functions should be clarified for accurate dose verification. In this study, we visualized the distribution of irradiated radioactive beams, 11 C and 15 O beams, in the rabbit whole-body using our original depth-of-interaction (DOI)-PET prototype to add basic data for biological washout effect correction. Time activity curves of the irradiated field and organs were measured immediately after the irradiations. All data were corrected for physical decay before further analysis. We also collected expired gas of the rabbit during beam irradiation and the energy spectrum was measured with a germanium detector. Irradiated radioactive beams into the brain were distributed to the whole body due to the biological washout process, and the implanted 11 C and 15 O ions were concentrated in the ...

中文翻译：

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束内PET的生物洗脱模型：11C和15O离子束辐照兔脑。

正电子发射断层扫描（PET）已用于带电粒子治疗中的剂量验证。应阐明通过生理功能冲洗正电子发射体的原因，以进行准确的剂量验证。在这项研究中，我们使用原始的相互作用深度（DOI）-PET原型为兔子的全身可视化了辐射的放射性束11 C和15 O束的分布，并添加了用于校正生物洗脱效应的基本数据。辐照后立即测量辐照场和器官的时间活动曲线。在进一步分析之前，对所有数据进行了物理衰减校正。我们还收集了束辐照期间兔子的呼出气体，并用锗探测器测量了能谱。