Nature has evolved to grow and regenerate tissues and organs using self-assembling processes capable of organizing a wide variety of molecular building-blocks at multiple size scales. As the field of biofabrication progresses, it is essential to develop innovative ways that can enhance our capacity to build more complex macroscopic structures using molecular and nanoscale components in a rational manner. In this review, we highlight the emerging opportunities, advantages, and challenges of incorporating self-assembly with biofabrication for the development of more biologically relevant, active, and functional structures. The review is organized in four sections. First, to better appreciate the benefits of this integrated approach, we summarize recent advances in self-assembly and biofabrication aimed at improving hierarchical control. Then, we discuss work focused on combining self-assembly with biofabrication in three areas including a) conventional bioprinting techniques using...

中文翻译：

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将自组装和生物制造相结合，以开发具有增强的复杂性和分级控制的结构。

大自然已经进化到使用能够以多种尺寸组织各种分子构建块的自组装过程来生长和再生组织和器官。随着生物制造领域的发展，必须开发创新的方法，以提高我们以合理的方式使用分子和纳米级组件构建更复杂的宏观结构的能力。在这篇综述中，我们强调了将自组装与生物制造相结合以开发更具生物学相关性、活性和功能性结构的新兴机遇、优势和挑战。审查分为四个部分。首先，为了更好地了解这种综合方法的好处，我们总结了旨在改善分层控制的自组装和生物制造的最新进展。然后，