Ethnicity impacts Alzheimer's disease risk, especially among Caribbean-Hispanics. We report the first RNA-sequencing analysis of brain tissue from 45 Alzheimer's disease and control Caribbean-Hispanics. Data were compared with two independent samples of non-Hispanic Caucasians (total n=729). By identifying and characterizing those genes with ancestry- and region-specific expression patterns in Alzheimer's disease, we reveal molecular insights that may help explain epidemiological disparities in this understudied aging population.

中文翻译：

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加勒比海西班牙阿兹海默氏症的大脑转录组揭示了特定于祖先的疾病机制

种族会影响阿尔茨海默氏病的风险，尤其是在加勒比海裔西班牙裔中。我们报告了来自45个阿尔茨海默氏病和对照加勒比海裔西班牙人的脑组织的首次RNA测序分析。将数据与非西班牙裔白种人的两个独立样本进行比较（总n = 729）。通过在阿尔茨海默氏病中鉴定具有祖先和区域特异性表达模式的基因并进行表征，我们揭示了分子的见解，可能有助于解释这一研究不足的老龄化人群的流行病学差异。