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Electrical properties, accuracy, and multi-day performance of gelatine phantoms for electrophysiology
bioRxiv - Bioengineering Pub Date : 2020-05-31 , DOI: 10.1101/2020.05.30.125070
Amani Yousef Owda , Alexander J. Casson

Gelatine based phantoms for electrophysiology are becoming widely used as they allow the controlled validation of new electrode and new instrumentation designs. The phantoms mimic the electrical properties of the human body and allow a pre-recorded electrophysiology signal to be played-out, giving a known signal for the novel electrode or instrumentation to collect. Such controlled testing is not possible with on-person experiments where the signal to be recorded is intrinsically unknown. However, despite the rising interest in gelatine based phantoms there is relatively little public information about their electrical properties and accuracy, how these vary with phantom formulation, and across both time and frequency. This paper investigates ten different phantom configurations, characterising the impedance path through the phantom and comparing this impedance path to both previously reported electrical models of Ag/AgCl electrodes placed on skin and to a model made from ex vivo porcine skin. This article shows how the electrical properties of the phantoms can be tuned using different concentrations of gelatine and of sodium chloride (NaCl) added to the mixture, and how these properties vary over the course of seven days for a.c. frequencies in the range 20-1000 Hz. The results demonstrate that gelatine phantoms can accurately mimic the frequency response properties of the body-electrode system to allow for the controlled testing of new electrode and instrumentation designs.

中文翻译:

明胶体模的电学性质,准确性和多日性能

基于明胶的电生理学模型被广泛使用,因为它们可以对新电极和新仪器设计进行可控验证。人体模型模仿人体的电学特性,可以播放预先记录的电生理信号,从而为新型电极或仪器收集已知信号。对于要记录的信号本质上是未知的亲自实验,这种受控测试是不可能的。然而,尽管人们对基于明胶的体模越来越感兴趣,但是关于其电学性质和准确性,它们随着体模配方以及在时间和频率上如何变化的公开信息相对较少。本文研究了十种不同的幻像配置,表征通过体模的阻抗路径,并将该阻抗路径与先前报道的放置在皮肤上的Ag / AgCl电极的电气模型以及由离体猪皮肤制成的模型进行比较。本文显示了如何使用添加到混合物中的不同浓度的明胶和氯化钠(NaCl)来调整幻影的电特性,以及在20-1000范围内的交流频率下,这些特性在7天的过程中如何变化赫兹。结果表明,明胶体模可以准确模拟人体电极系统的频率响应特性,从而可以对新电极和仪器设计进行受控测试。本文显示了如何使用添加到混合物中的不同浓度的明胶和氯化钠(NaCl)来调整幻影的电特性,以及在20-1000范围内的交流频率下,这些特性在7天的过程中如何变化赫兹。结果表明,明胶体模可以准确模拟人体电极系统的频率响应特性,从而可以对新电极和仪器设计进行受控测试。本文介绍了如何使用添加到混合物中的不同浓度的明胶和氯化钠(NaCl)来调整幻影的电特性,以及在20-1000范围内的交流频率下,这些特性在7天的过程中如何变化赫兹。结果表明,明胶体模可以准确模拟人体电极系统的频率响应特性,从而可以对新电极和仪器设计进行受控测试。
更新日期:2020-05-31
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