The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural engineering. Bioelectronic devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of interest. We demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes (4.5-µm thick) through dura mater and thick epineurium. The diamond shuttle has 54% less cross-sectional area than an equivalently stiff silicon shuttle, which we simulated will result in a 37% reduction in blood vessel damage. We also discovered that higher frequency oscillation of the shuttle (200 Hz) significantly reduced tissue compression regardless of the insertion speed, while slow speeds also independently reduced tissue compression. Insertion and recording performance are demonstrated in rat and feline models, but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

通过中枢和周围神经系统最坚韧的膜提供灵活的生物传感器的能力是神经科学和神经工程中的一个重要挑战。通过硬脑膜和厚神经外膜植入的生物电子设备在到达感兴趣的神经元时理想地会产生最小的压缩和急性损伤。我们证明，可以通过垂直支撑轻松制作三维金刚石梭，以通过硬脑膜和厚神经外膜提供超顺应性聚合物微电极（4.5 µm 厚）。金刚石梭子的横截面积比同等硬度的硅梭子小 54%，我们模拟这将导致血管损伤减少 37%。我们还发现，无论插入速度如何，梭子的较高频率振荡（200 Hz）都会显着减少组织压缩，而低速也可以独立减少组织压缩。插入和记录性能在大鼠和猫科动物模型中得到了证明，但这些工具的巨大设计空间适合各种动物模型和神经系统目标的研究。