Poly(N-isopropylacrylamide) (PNIPAAm)-based thermally responsive micelles are of great importance as smart materials for a number of applications such as drug delivery and biosensing, owing to their tunable lower critical solution temperature (LCST). Their design and synthesis in the nanoscale size range have been widely studied, and research interest in their structural and physic-chemical properties is continually growing. In this Viewpoint, representative research on the construction of PNIPAAm-based thermally responsive micelles as well as their applications are highlighted and discussed, which would serve as a good start for newcomers in this field and a positive guide for future research.

中文翻译：

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高分子科学100周年视点：聚（N-异丙基丙烯酰胺）基热响应胶束

基于聚 ( N-异丙基丙烯酰胺) (PNIPAAm) 的热响应胶束由于其可调节的较低临界溶解温度 (LCST) 而在药物输送和生物传感等许多应用中作为智能材料非常重要。它们在纳米尺寸范围内的设计和合成已被广泛研究，对其结构和物理化学性质的研究兴趣不断增长。在此观点中，重点讨论了基于PNIPAAm的热响应胶束的构建及其应用的代表性研究，这将为该领域的新人提供良好的开端，并为未来的研究提供积极的指导。