当前位置: X-MOL 学术Biotech. Histochem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of Juglans regia L. leaf extract supplementation on testicular functions in diabetic rats.
Biotechnic & Histochemistry ( IF 1.6 ) Pub Date : 2020-06-01 , DOI: 10.1080/10520295.2020.1755893
Davood Nasiry 1 , Ali Reza Khalatbary 2 , Hassan Ahmadvand 3 , Fereshteh Beigom Talebpour Amiri 2
Affiliation  

ABSTRACT

Testicular dysfunction is a complication of diabetes mellitus (DM). Juglans regia L. (JRL) leaf extract is a source of phenolic compounds that exhibits hypoglycemic and antioxidative properties. We investigated whether JRL leaf extract could inhibit the adverse effects of DM on oxidative stress, testis histology and testosterone hormone production. We used four groups of male rats: control group (non-diabetic) given saline, diabetic group, diabetic + JRL group that received JRL leaf extract, and JRL group (nondiabetic) that received JRL leaf extract only. To evaluate the effects of JRL leaf extract on testicular functions in diabetic animals, we evaluated histopathological and histomorphometric changes; serum testosterone; and malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. Decreased of MDA along with improved antioxidant status in the testis of diabetic rats; these abnormalities were attenuated by JRL leaf extract. We detected significantly decreased antioxidant biomarkers (GSH, SOD, CAT) and testosterone levels in the diabetic rats; these levels were normalized after JRL leaf extract administration. The MDA level and improved antioxidant status in the testis of diabetic rats was detected after JRL leaf extract administration. Our findings suggest that JRL leaf extract exerts preventive effects against diabetic dysfunction in the testis, which might be due to its antioxidant, anti-inflammatory and anti-apoptotic properties.



中文翻译:

补充胡桃提取物对糖尿病大鼠睾丸功能的影响。

摘要

睾丸功能障碍是糖尿病(DM)的并发症。核桃L. (JRL) 叶提取物是酚类化合物的来源,具有降血糖和抗氧化特性。我们研究了 JRL 叶提取物是否可以抑制 DM 对氧化应激、睾丸组织学和睾酮激素产生的不利影响。我们使用了四组雄性大鼠:对照组(非糖尿病)给予盐水,糖尿病组,糖尿病+JRL组接受JRL叶提取物,JRL组(非糖尿病)只接受JRL叶提取物。为了评估 JRL 叶提取物对糖尿病动物睾丸功能的影响,我们评估了组织病理学和组织形态学变化;血清睾酮;和丙二醛 (MDA)、谷胱甘肽 (GSH)、超氧化物歧化酶 (SOD) 和过氧化氢酶 (CAT) 水平。糖尿病大鼠睾丸中 MDA 的减少和抗氧化状态的改善;JRL 叶提取物减弱了这些异常。我们检测到糖尿病大鼠的抗氧化生物标志物(GSH、SOD、CAT)和睾酮水平显着降低;这些水平在 JRL 叶提取物给药后标准化。在 JRL 叶提取物给药后,检测了糖尿病大鼠睾丸中 MDA 水平和改善的抗氧化状态。我们的研究结果表明,JRL 叶提取物对睾丸中的糖尿病功能障碍具有预防作用,这可能是由于其抗氧化、抗炎和抗凋亡特性。在 JRL 叶提取物给药后,检测了糖尿病大鼠睾丸中 MDA 水平和改善的抗氧化状态。我们的研究结果表明,JRL 叶提取物对睾丸中的糖尿病功能障碍具有预防作用,这可能是由于其抗氧化、抗炎和抗凋亡特性。在 JRL 叶提取物给药后,检测了糖尿病大鼠睾丸中 MDA 水平和改善的抗氧化状态。我们的研究结果表明,JRL 叶提取物对睾丸中的糖尿病功能障碍具有预防作用,这可能是由于其抗氧化、抗炎和抗凋亡特性。

更新日期:2020-06-01
down
wechat
bug