Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.

中文翻译：

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当氧化应激遇到表观遗传学时：对癌症发展的影响。

癌症是全球范围内主要的死亡原因之一，它可以影响生物体的任何部分。它是遗传和表观遗传变化的结果，导致细胞不受控制的生长。表观遗传机制可以调节基因表达而无需改变DNA序列，它包括DNA的甲基化，组蛋白修饰和非编码RNA。这些基因表达调节元件的改变可通过细胞内环境的失衡产生，例如由氧化应激衍生的细胞内环境的失衡，以促进癌症的发展，进展和对化学疗法的抵抗。在这里，我们回顾了有关表观遗传机制中氧化应激影响的当前文献，尤其是在很大程度上未知的ncRNA及其对癌症发展和进展的影响方面。