The aim of the present study was to evaluate the influence of the incorporation of caffeine as a model active ingredient on the quality attributes of a bioadhesive emulgel formulation previously optimized by Quality by Design (QbD) tools. Emulgels are emerging topical drug delivery systems for cosmetic or pharmaceutical uses, which combine the advantages of both emulsions and gels.

中文翻译：

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基于使用 QbD 工具的配方设计，用于化妆品应用的咖啡因生物粘附乳液的制备和评估。

本研究的目的是评估加入咖啡因作为模型活性成分对先前通过质量源于设计 (QbD) 工具优化的生物粘附乳液制剂的质量属性的影响。Emulgels 是新兴的用于化妆品或药物用途的局部给药系统，它结合了乳液和凝胶的优点。