The content of dermal beta‐carotene can be a good indicator showing the body health. Because, it is involved in production of vitamin A maintaining healthy skin and mucous membranes. Also, it reduces the risk of cardiovascular diseases and its antioxidant capacity prevents the formation of cancerous cells. In this work, we use Raman spectroscopy and a low‐cost diffuse reflectance spectroscopy (DRS) to detect the dermal beta‐carotene spectra. We apply computational optical clearing (OC) method to in vivo evaluation the concentration of this chromophore. The results show that Raman spectroscopy is a good tool for in vitro detection of carotenoids but is not able to clearly discriminate the individual carotenoids in skin tissue in vivo. The results also show that using OC enhances the ability of low‐cost diffuse reflection spectroscopy for in vivo detection of dermal beta‐carotene in humans. This method can be used as a low‐cost and portable device to screening the concentration of chromophores such as melanin and carotenoid molecules for oncological studies.

中文翻译：

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使用计算光学清除技术对人皮肤中的β-胡萝卜素进行体内检测。

皮肤中β-胡萝卜素的含量可以很好地表明人体健康。因为，它参与了维他命A的生产，维持了健康的皮肤和粘膜。而且，它降低了心血管疾病的风险，其抗氧化能力可以防止癌细胞的形成。在这项工作中，我们使用拉曼光谱和低成本的漫反射光谱（DRS）来检测皮肤β-胡萝卜素光谱。我们应用计算光学清除（OC）方法在体内评估该发色团的浓度。结果表明，拉曼光谱法是体外检测类胡萝卜素的良好工具，但不能在体内清楚地区分皮肤组织中的单个类胡萝卜素。结果还表明，使用OC可以增强低成本漫反射光谱法在人体中检测人体皮肤β-胡萝卜素的能力。该方法可作为低成本便携式设备用于筛查发色团（例如黑色素和类胡萝卜素分子）的浓度以进行肿瘤学研究。