The development of novel compounds that trigger non‐apoptotic cell death may represent alternative therapeutic strategies for esophageal squamous cell carcinoma (ESCC) treatment. Cellular senescence suppresses tumorigenesis by halting the proliferation of tumor cells, implying the induction of senescence as a promising anticancer strategy, especially when combined with senolytic agents that specially kill senescent cells. This study is designed to screen novel anti‐ESCC compounds from a natural product resource and identify its mechanism‐of‐action.

中文翻译：

---

萝卜硫素通过调节mTOR / TFE3抑制自噬并诱导外来体介导的旁分泌衰老。

引发非凋亡性细胞死亡的新型化合物的开发可能代表了食管鳞状细胞癌（ESCC）治疗的替代治疗策略。细胞衰老通过停止肿瘤细胞的增殖来抑制肿瘤的发生，这意味着诱导衰老是一种有前途的抗癌策略，尤其是与能专门杀死衰老细胞的衰老剂联合使用时。本研究旨在从天然产物资源中筛选新型抗ESCC化合物，并确定其作用机理。