Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Cystic fibrosis transmembrane conductance regulator is extensively expressed in the intestine and has an important role in the regulation of the viscosity and pH of gut secretions. Several studies have reported a delay in small bowel and colonic transit times in patients with CF which have been attributed to the secretory dysfunction. Our aim was to determine whether intestinal contractility is affected in these patients.

中文翻译：

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囊性纤维化中肠的运动功能障碍。

囊性纤维化（CF）是一种由囊性纤维化跨膜电导调节剂（CFTR）蛋白突变引起的多系统疾病。囊性纤维化跨膜电导调节剂在肠道中广泛表达，在调节肠道分泌物的粘度和pH值方面具有重要作用。几项研究报告了CF患者小肠和结肠转运时间的延迟，这归因于分泌功能障碍。我们的目的是确定这些患者的肠道收缩力是否受到影响。