Trichosanlhes kirilowii Maxim seed oil (TSO) is rich in conjugated linolenic acids, and the flavonoids (FLA) combined with n‐3 fatty acids can effectively change the plasma antioxidant capacity. Hyperlipidemia and oxidative stress are one of the most important risk factors for cardiovascular disease. This study aims to evaluate the effect of the TSO, FLA, and TSO combined with FLA (TSOFLA) intake on hyperlipemia mice. TSO and TSOFLA administration resulted in a significant decline in serum levels of total cholesterol, triglycerides, and low density lipoprotein‐cholesterol. TSOFLA improved the hepatic and serum antioxidant status as assessed by superoxide dismutase, glutathione peroxidase activities, and reduced the levels of lipid peroxidation. Hematoxylin‐eosin staining of liver and aorta tissue has shown a marked reduction of the hyperlipidemia‐induced lesions by gavage TSOFLA. Compared with TSO and FLA, TSOFLA has more significant hypolipidemic and antioxidant activities, which effects may be correlated to the synergy between TSO and FLA.

中文翻译：

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饲喂高脂饮食的小鼠天花粉seed种子油和类黄酮的降脂和抗氧化活性。

毛滴虫Maxim种子油（TSO）富含共轭亚麻酸，而类黄酮（FLA）与n-3脂肪酸结合可有效改变血浆抗氧化能力。高脂血症和氧化应激是心血管疾病最重要的危险因素之一。这项研究旨在评估TSO，FLA和TSO联合FLA（TSOFLA）摄入对高脂血症小鼠的影响。TSO和TSOFLA的使用导致血清总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇水平显着下降。通过超氧化物歧化酶，谷胱甘肽过氧化物酶活性评估，TSOFLA可改善肝和血清抗氧化状态，并降低脂质过氧化水平。肝和主动脉组织的苏木精-伊红染色显示，强饲TSOFLA可显着减少高脂血症引起的病变。与TSO和FLA相比，TSOFLA具有更显着的降血脂和抗氧化活性，其作用可能与TSO和FLA之间的协同作用有关。