Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.,Cytometry Part B: Clinical Cytometry

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Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.
Cytometry Part B: Clinical Cytometry ( IF 3.4 ) Pub Date : 2020-06-01 , DOI: 10.1002/cyto.b.21882
Paola Bonaccorso _{1,

2} , Cristina Bugarin ₁ , Chiara Buracchi ₁ , Grazia Fazio ₁ , Andrea Biondi _{1,

3} , Luca Lo Nigro ₂ , Giuseppe Gaipa ₁

Affiliation

The PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T‐cell acute lymphoblastic leukemias (T‐ALLs). Although loss‐of‐function of phosphatase and tensin homolog (PTEN) is a common event in pediatric T‐ALLs, the exact role of this tumor suppressor in T‐ALL development has yet to be defined.

中文翻译：

儿科 T 细胞急性淋巴细胞白血病的单细胞分析：PTEN 外显子 7 突变对 PI3K/Akt 和 JAK-STAT 信号通路的影响。

PI3K/Akt/mTOR (PI3K) 信号通路在 T 细胞急性淋巴细胞白血病 (T-ALL) 中起关键作用。尽管磷酸酶和张力蛋白同源物 (PTEN) 的功能丧失是儿科 T-ALL 中的常见事件，但这种肿瘤抑制因子在 T-ALL 发展中的确切作用尚未确定。

更新日期：2020-06-01

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