Coptisine is an alkaloid with many biological functions, but studies on its mechanism in myocardial ischemia-reperfusion (I/R) injury are less reported. Hypoxia–reoxygenation (H/R) -treated cardiomyocytes injury and I/R-induced myocardial tissues damage were created in rat models with or without the pre-treatment of coptisine. The proliferation and apoptosis of cardiomyocytes and changes of myocardial tissues were observed after the pre-treatment of coptisine. The pre-treatment of coptisine promoted cell proliferation and inhibited apoptosis of H/R-injured cardiomyocytes, and alleviated the myocardial tissue injury caused by I/R in rats. Moreover, coptisine promoted the expressions of anti-apoptotic proteins and inhibited the expressions of pro-apoptotic proteins in vivo and in vitro. The current study found that coptisine had protective effects on I/R-induced myocardial damage, which may provide a new insight into the treatment of I/R.

黄连碱是一种具有多种生物学功能的生物碱，但有关其在心肌缺血/再灌注（I / R）损伤中作用机理的研究报道较少。缺氧复氧（H / R）处理的心肌细胞损伤和I / R诱导的心肌组织损伤在大鼠模型中进行或不进行黄连碱预处理。黄连碱预处理后，观察到心肌细胞的增殖和凋亡以及心肌组织的变化。黄连碱的预处理促进了H / R损伤的心肌细胞的增殖并抑制了其凋亡，减轻了I / R引起的心肌组织损伤。此外，黄连素在体内和体外均能促进抗凋亡蛋白的表达并抑制促凋亡蛋白的表达。。当前的研究发现黄连对I / R引起的心肌损伤具有保护作用，这可能为I / R的治疗提供新的见解。