A water- and alcohol-soluble cerium oxide-curcumin conjugate was obtained by co-evaporation with poly(N-vinylpyrrolidone) (PVP). A nanocomposite consisting of hybrid organic-inorganic particles was stable in a wide range of pH values. Its properties were evaluated using nine cell lines: normal (MDBK, ST, Vero) and malignant (L929, T98G, HEp-2, A549, RIN-m5F, Hep G2). PVP-stabilised nanoceria was shown to inhibit autoxidation of curcumin, to enhance curcumin photostability, to promote bioaccumulation and to affect curcumin cytotoxicity and photocytotoxicity, depending on cell type, being more toxic to cancer cells in a selective manner. Under the conditions of UVA/UVC or H₂O₂-induced oxidative stress, the nanoceria-PVP-curcumin (NPC) conjugate was found to possess a selective cytotoxicity: it caused drastic inhibition of metabolic activity or a decrease in the total number of tumour cells, while in non-transformed cultures under the same conditions, the nanoceria-PVP-curcumin conjugate protected cells from these damaging factors. The NPC-conjugate, unlike curcumin itself, demonstrated a photosensitising effect in tumour cell cultures, while protecting non-transformed cultures from the damaging effects of UV radiation or oxidative stress. Based on the results obtained, we strongly believe that this novel hybrid material has enhanced characteristics compared to other curcumin formulations, and can be considered as a potent drug for biomedical applications, including cancer therapy.

通过与聚（N-乙烯基吡咯烷酮）（PVP）共蒸发获得水溶性和醇溶性氧化铈-姜黄素共轭物。由杂化有机-无机颗粒组成的纳米复合材料在很宽的pH值范围内都是稳定的。使用九种细胞系评估其性质：正常（MDBK，ST，Vero）和恶性（L929，T98G，HEp-2，A549，RIN-m5F，Hep G2）。PVP稳定的纳米氧化铈可抑制姜黄素的自氧化，增强姜黄素的光稳定性，促进生物蓄积并影响姜黄素的细胞毒性和光细胞毒性（取决于细胞类型），对癌细胞具有选择性毒性。在UVA / UVC或H ₂ O ₂的条件下氧化应激诱导的氧化铈-PVP-姜黄素（NPC）结合物具有选择性的细胞毒性：它引起代谢活性的急剧抑制或肿瘤细胞总数的减少，而在相同条件下的非转化培养物中在这种情况下，纳米氧化铈-PVP-姜黄素缀合物可保护细胞免受这些破坏性因素的侵害。与姜黄素本身不同，NPC-缀合物在肿瘤细胞培养物中表现出光敏作用，同时保护未转化的培养物免受紫外线辐射或氧化应激的破坏作用。根据获得的结果，我们坚信与其他姜黄素制剂相比，这种新型杂化材料具有增强的特性，可以被认为是包括癌症治疗在内的生物医学应用的有效药物。