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Role of amino acids in regulation of ROS balance in cancer.
Archives of Biochemistry and Biophysics ( IF 3.9 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.abb.2020.108438
Emilie Jaune-Pons 1 , Sophie Vasseur 1
Affiliation  

Cancer cells display increased oxidative stress from reactive oxygen species (ROS) and constantly have to counteract them below a tolerable threshold to avoid any toxicity due to overload of ROS. The involvement of ROS in cancer progression from precursor lesions to aggressive tumor and metastasis formation is still debated, but it is recognized that cancer cells succeed to use ROS for their own benefit in circumstances that are tumor cell-type specific. In this review, we focus on amino acids’ metabolic pathways that tumor cells activate as antioxidants including cysteine, methionine metabolisms and their connection with the folate, transulfuration pathways and ferroptosis. We discuss how the tumor context definitively dictates the impact of ROS on tumor progression towards a metastatic disease as well as the therapeutic approaches that target ROS to abrogate tumors or limit their aggressiveness.



中文翻译:

氨基酸在癌症中调节ROS平衡中的作用。

癌细胞表现出来自活性氧(ROS)的增加的氧化应激,并且必须不断地在低于可耐受的阈值下抵消它们,以免由于ROS过载而产生任何毒性。ROS参与从前体病变发展到侵袭性肿瘤和转移形成的癌症仍在争论中,但是已经认识到癌细胞在特定于肿瘤细胞类型的情况下成功利用ROS来获得自己的利益。在这篇综述中,我们集中于肿瘤细胞作为抗氧化剂而激活的氨基酸代谢途径,包括半胱氨酸,蛋氨酸的代谢以及它们与叶酸,转硫途径和肥大症的联系。

更新日期:2020-06-29
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