Abstract

Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of theranostics. To date, a number of promising agents based on nanomaterials capable of diagnosing, targeted therapeutic effects, and monitoring the response of tumor cells were obtained within the approach of theranostics. In this work, a new type of theranostic complexes based on upconversion nanoparticles coated with polyethylene glycol and functionalized with the DARPin–LoPE recombinant targeted toxin was developed. Selective binding of complexes to human breast adenocarcinoma cells overexpressing the HER2 receptor and specific toxicity to them were shown.

中文翻译：

---

基于光致发光上转换纳米粒子的多功能配合物用于HER2阳性肿瘤的治疗学。

摘要

在一种药物中结合诊断和治疗功能是开发个性化治疗癌症方法的一种有前途的策略。随着纳米生物技术的发展，诊断和治疗相结合的机会出现了，并且在治疗学的概念中得到了实现。迄今为止，在治疗诊断学的方法中获得了许多基于纳米材料的有前途的试剂，这些试剂能够诊断，靶向治疗并监测肿瘤细胞的反应。在这项工作中，基于涂有聚乙二醇并用DARPin-LoPE重组靶向毒素功能化的上转换纳米颗粒，开发了一种新型的治疗化合物。