A soft coral-derived fungus Penicillium sp. among other isolates e high antibacterial, anti-yeast and cytotoxic activities. The fungus, Penicillium sp . MMA, isolated from Sarcphyton glaucoma, afforded nine diverse compounds ( 1 – 9 ). Their structures were identified by 1D and 2 D NMR and ESI–MS spectroscopic data as two alkaloids: veridicatol ( 1 ), aurantiomide C ( 2 ); one sesquiterpene, aspterric acid ( 3 ); two carboxylic acids, 3,4-dihydroxy-benzoic acid; ( 4 ) and linoleic acid ( 5 ); three steroids, ergosterol ( 6 ), β -Sitosterol ( 7 ), β -Sitosterol glucoside ( 8 ) along with the sphingolipid, cerebroside A ( 9 ). Biologically, the antimicrobial, antioxidant, in vitro cytotoxicity and antibiofilm activities were studied in comparison with the fungal extract. The in silico computational studies were implemented to predict drug and lead likeness properties for 1–4 . The fungus was taxonomically characterized by morphological and molecular biology (18srRNA) approaches.

中文翻译：

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来自青霉菌属的多种生物活性代谢物。来自红海的MMA：结构鉴定和生物活性研究

一种软珊瑚衍生的真菌 Penicillium sp。除其他分离物外，还具有高抗菌、抗酵母和细胞毒活性。真菌，青霉菌属。从肉癣菌青光眼中分离出的 MMA 提供了九种不同的化合物 (1-9)。它们的结构通过一维和二维 NMR 和 ESI-MS 光谱数据确定为两种生物碱：藜芦醇 (1)、金黄胺 C (2)；一种倍半萜、天冬氨酸（3）；两种羧酸，3,4-二羟基苯甲酸；(4)和亚油酸(5)；三种类固醇，麦角甾醇 (6)、β-谷甾醇 (7)、β-谷甾醇葡萄糖苷 (8) 以及鞘脂、脑苷脂 A (9)。在生物学上，与真菌提取物相比，研究了抗微生物、抗氧化、体外细胞毒性和抗生物膜活性。实施了计算机计算研究来预测 1-4 的药物和铅相似特性。通过形态学和分子生物学 (18srRNA) 方法对真菌进行分类学表征。