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Carboxymethyl Cellulose-Based Hydrogel: Dielectric Study, Antimicrobial Activity and Biocompatibility
Arabian Journal for Science and Engineering ( IF 2.9 ) Pub Date : 2020-05-31 , DOI: 10.1007/s13369-020-04655-8
Gamal Turky , Mohammed A. Moussa , Mohamed Hasanin , Naglaa Salem El-Sayed , Samir Kamel

In this work, we intended to investigate the antimicrobial activity, biocompatibility, and study the electrical conductivity of the polypyrrole on the surface of the conducting hydrogel such as carboxymethyl cellulose-g-poly (acrylamide-co-acrylamido-2-methyl-1-propane sulfonic acid). Broadband dielectric spectroscopy was employed to follow up the electrochemical double layer that developed at the electrode surfaces. Biocompatible conducting hydrogel showed the establishment of the electrical double layer in a wide range of frequencies, and the DC-conductivity values were in top of the semiconductors range. The addition of polypyrrole not only diminishes the effect of water transformations on conductivity, but also manifests the permittivity’s value (from 1.7 × 106 to 2.4 × 108). In addition, it lowers the charging–discharging loss of energy. Comparing the prepared conductive hydrogels to the ionic liquids, it showed that hydrogels have more ability to be applicable in the energy storage systems. Also, the prepared hydrogels biocompatibility was tested against normal cell line (Vero cells) which recorded the excellent compatibility with cells. The antimicrobial activity was examined against some pathogens; (i) Gram-negative bacteria: Escherichia coli (NCTC-10416) and Pseudomonas aeruginosa (NCID-9016); (ii) Gram-positive bacteria: Bacillus subtilis (NCID-3610); (iii) unicellular fungi: Candida albicans (NCCLS-11) and (iv) filamentous fungi Aspergillus niger (ATCC-22342).



中文翻译:

羧甲基纤维素基水凝胶:介电研究,抗菌活性和生物相容性

在这项工作中,我们打算研究抗菌活性,生物相容性,并研究导电水凝胶表面上的聚吡咯的电导率,例如羧甲基纤维素-g-聚(丙烯酰胺-co-丙烯酰胺基-2-甲基-1-丙烷磺酸)。宽带介电谱用于跟踪在电极表面形成的电化学双层。生物相容性导电水凝胶显示出在很宽的频率范围内双电层的建立,并且直流电导率值在半导体范围之内。聚吡咯的添加不仅减少了水转化对电导率的影响,而且还显示出介电常数的值(从1.7×10 6到2.4×10 8)。另外,它降低了能量的充放电损耗。将制备的导电水凝胶与离子液体进行比较,结果表明水凝胶具有更大的能力适用于储能系统。而且,针对记录的与细胞的优异相容性的正常细胞系(Vero细胞)测试了所制备的水凝胶的生物相容性。检查了对某些病原体的抗菌活性;(i)革兰氏阴性菌:大肠杆菌(NCTC-10416)和铜绿假单胞菌(NCID-9016);(ii)革兰氏阳性细菌:枯草芽孢杆菌(NCID-3610);(iii)单细胞真菌:白色念珠菌(NCCLS-11)和(iv)丝状真菌黑曲霉(ATCC-22342)。

更新日期:2020-05-31
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