Previous studies have suggested that taurine has hypoglycemic and hypolipidemic effects on experimental diabetic models. Therefore, this clinical trial was designed to explore the impacts of taurine supplementation on glycemic control and lipid profile in the patients with T2DM. This study was conducted on 45 patients with T2DM in Tabriz Sheikhor-raees Polyclinic and Imam-Reza Hospital Endocrine Center. Subjects were randomly divided into taurine and placebo groups. Accordingly, the taurine group (n = 23) received taurine 3000 mg/daily and the placebo group (n = 22) took crystalline microcellulose/daily for the duration of 8 weeks. At baseline and after the trial completion, fasting blood samples were obtained from the patients to assess the glycemic indicators and lipid profile. Independent t test, paired t test, Pearson’s correlation, and analysis of covariance was used for analysis. At the end of the study, levels of FBS (p = 0.01), insulin (p = 0.01), HOMA-IR (p = 0.003), TC (p = 0.013), and LDL-C (p = 0.041) significantly decreased in the taurine group compared to the placebo group. In addition, there was no significant changes in HbA1c, triglyceride, HDL-C, anthropometric indicators or dietary intakes by passing 8 weeks from the intervention. In conclusion, the findings of the current study indicated that taurine supplementation (3000 mg/day) for 8 weeks could improve the glycemic indexes and lipid profiles including TC and LDL-C in the patients with T2DM.

中文翻译：

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补充牛磺酸对2型糖尿病患者的血糖控制和血脂水平的影响：一项随机，双盲，安慰剂对照试验。

先前的研究表明，牛磺酸对实验性糖尿病模型具有降血糖和降血脂作用。因此，该临床试验旨在探讨牛磺酸补充剂对T2DM患者血糖控制和血脂水平的影响。这项研究是在大不里士谢赫尔雷兹综合诊所和伊玛目-雷扎医院内分泌中心对45例T2DM患者进行的。将受试者随机分为牛磺酸和安慰剂组。因此，牛磺酸组（n  = 23）每天接受牛磺酸3000 mg，安慰剂组（n = 23）。 ＝ 22）/每天服用结晶性微纤维素，持续8周。在基线和试验完成后，从患者那里获取空腹血样，以评估血糖指标和血脂水平。使用独立t检验，配对t检验，Pearson相关性和协方差分析进行分析。在研究结束时，FBS（p  = 0.01），胰岛素（p  = 0.01），HOMA-IR（p  = 0.003），TC（p  = 0.013）和LDL-C（p = 0.041）与安慰剂组相比，牛磺酸组显着降低。此外，从干预开始经过8周，HbA1c，甘油三酸酯，HDL-C，人体测量指标或饮食摄入量均无显着变化。总之，当前研究的结果表明，连续2周补充牛磺酸（3000 mg /天）可以改善T2DM患者的血糖指数和脂质谱，包括TC和LDL-C。