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Genotype constellation of a rotavirus A field strain with an uncommon G8P[11] genotype combination in a rotavirus-vaccinated dairy cattle herd.
Archives of Virology ( IF 2.7 ) Pub Date : 2020-05-29 , DOI: 10.1007/s00705-020-04675-7
Juliana T T Fritzen 1 , Marcos V Oliveira 1 , Elis Lorenzetti 1, 2, 3 , Alice F Alfieri 1, 3 , Amauri A Alfieri 1, 4
Affiliation  

In this report we describe the genotype constellation of a bovine rotavirus A (RVA) strain with an uncommon G8P[11] genotype combination. The RVA/Cow-wt/BRA/Y136/2017/G8P[11] strain was classified as G8-P[11]-I2-R5-C2-M2-A3-N2-T9-E2-H3. Phylogenetic analysis based on the VP7 gene showed that the Y136 strain and a human G8P[1] strain comprise a putative new (VII) lineage for the G8 genotype. In addition, two other genotypes, R5 (VP1) and T9 (NSP3), were identified in the constellation of Y136 that are rarely found in RVA strains of bovine origin. The immunological pressure caused by regular vaccination of cows might be responsible for the selection of heterologous RVA strains.



中文翻译:

轮状病毒接种的奶牛群中具有罕见的G8P [11]基因型组合的轮状病毒A田间菌株的基因型构象。

在本报告中,我们描述了具有罕见G8P [11]基因型组合的牛轮状病毒A(RVA)菌株的基因型构象。RVA / Cow-wt / BRA / Y136 / 2017 / G8P [11]菌株被分类为G8-P [11] -I2-R5-C2-M2-A3-N2-T9-E2-H3。基于VP7基因的系统发育分析表明,Y136菌株和人G8P [1]菌株包含针对G8基因型的推定新(VII)谱系。另外,在Y136星座中鉴定出了其他两种基因型,即R5(VP1)和T9(NSP3),这在牛源RVA株中很少见。定期接种牛引起的免疫压力可能是选择异源RVA菌株的原因。

更新日期:2020-07-13
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