BACKGROUND Increased risk for the future development of Alzheimer disease begins as early as midlife. Algorithm-based scores, such as the Cardiovascular Risk Factors, Aging and Incidence of Dementia (CAIDE) dementia risk score, and the Framingham general cardiovascular disease (CVD) risk score, have been used to determine future risk for the development of cognitive decline and dementia. We evaluated the association between neuroimaging and cognitive measures with the 2 risk scores in middle-aged, cognitively intact adults (49±6 y). METHODS In a cohort of 132 participants collected in 2014, magnetic resonance imaging was used to determine measures of cortical thickness in a priori regions of interest and a neuropsychological battery to assess memory and executive function. RESULTS The CAIDE dementia risk score was significantly and inversely associated with the cortical thickness of the parahippocampal (r=-0.266; P=0.002) and superior frontal gyrus (r=-0.261; P=0.002) despite a considerable percentage of individuals (99.3%) at low risk for CVD. There was a significant negative association between CAIDE and memory (r=-0.251; P=0.003). Framingham general CVD score was not associated with brain structure or cognitive function. CONCLUSIONS These results indicate that the CAIDE dementia risk score is associated with cortical thickness and cognitive function at midlife in a low-risk population. These data provide insight into subclinical structural and functional changes occurring during midlife associated with future risk for the development of dementia.

中文翻译：

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低危中年人痴呆和血管风险评分与皮质厚度和认知的关联。

背景早在中年就开始增加阿尔茨海默病未来发展的风险。基于算法的评分，例如心血管危险因素、老年痴呆症发病率 (CAIDE) 痴呆风险评分和弗雷明汉一般心血管疾病 (CVD) 风险评分，已被用于确定未来发展为认知能力下降的风险和痴呆。我们评估了神经影像学和认知测量与认知完整的中年成人（49±6 岁）的 2 个风险评分之间的关​​联。方法 在 2014 年收集的 132 名参与者队列中，使用磁共振成像来确定先验感兴趣区域的皮质厚度测量值，并使用神经心理学电池来评估记忆和执行功能。结果 CAIDE 痴呆风险评分与海马旁皮质 (r=-0.266; P=0.002) 和额上回 (r=-0.261; P=0.002) 的皮质厚度显着负相关，尽管个体比例相当大 (99.3 %) CVD 风险低。CAIDE 与记忆之间存在显着的负相关（r=-0.251；P=0.003）。Framingham 一般 CVD 评分与大脑结构或认知功能无关。结论 这些结果表明，CAIDE 痴呆风险评分与低风险人群的中年皮质厚度和认知功能相关。这些数据提供了对中年期间发生的亚临床结构和功能变化的洞察，这些变化与未来患痴呆症的风险相关。266; P=0.002) 和额上回 (r=-0.261; P=0.002) 尽管相当大比例的个体 (99.3%) 处于低 CVD 风险。CAIDE 与记忆之间存在显着的负相关（r=-0.251；P=0.003）。Framingham 一般 CVD 评分与大脑结构或认知功能无关。结论 这些结果表明，CAIDE 痴呆风险评分与低风险人群的中年皮质厚度和认知功能相关。这些数据提供了对中年期间发生的亚临床结构和功能变化的洞察，这些变化与未来患痴呆症的风险相关。266; P=0.002) 和额上回 (r=-0.261; P=0.002) 尽管相当大比例的个体 (99.3%) 处于低 CVD 风险。CAIDE 与记忆之间存在显着的负相关（r=-0.251；P=0.003）。Framingham 一般 CVD 评分与大脑结构或认知功能无关。结论 这些结果表明，CAIDE 痴呆风险评分与低风险人群的中年皮质厚度和认知功能相关。这些数据提供了对中年期间发生的亚临床结构和功能变化的洞察，这些变化与未来患痴呆症的风险相关。CAIDE 与记忆之间存在显着的负相关（r=-0.251；P=0.003）。Framingham 一般 CVD 评分与大脑结构或认知功能无关。结论 这些结果表明，CAIDE 痴呆风险评分与低风险人群的中年皮质厚度和认知功能相关。这些数据提供了对中年期间发生的亚临床结构和功能变化的洞察，这些变化与未来患痴呆症的风险相关。CAIDE 与记忆之间存在显着的负相关（r=-0.251；P=0.003）。Framingham 一般 CVD 评分与大脑结构或认知功能无关。结论 这些结果表明，CAIDE 痴呆风险评分与低风险人群的中年皮质厚度和认知功能相关。这些数据提供了对中年期间发生的亚临床结构和功能变化的洞察，这些变化与未来患痴呆症的风险相关。