The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. Furthermore, Zn has the ability to enhance innate and adaptive immunity in the course of a viral infection. Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the infected cell can stop SARS-CoV-2 replication. Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19.

当前由 SARS-CoV-2 引起的 COVID-19 大流行促使全世界的研究人员寻找有效的抗病毒治疗方法。已推荐使用利巴韦林、瑞德西韦、洛匹那韦/利托那韦等多种抗病毒药物、阿奇霉素和强力霉素等抗生素以及伊维菌素等抗寄生虫药物用于 COVID-19 治疗。此外，已经提供了足够的临床前依据和证据来使用氯喹治疗 COVID-19。此外，锌具有在病毒感染过程中增强先天性和适应性免疫的能力。此外，锌补充剂可以有利于使用那些建议和/或推荐的药物治疗 COVID-19。同样，使用氯喹作为离子载体可以增强 Zn 的有效性，而感染细胞内的 Zn 可以阻止 SARS-CoV-2 复制。